In Russia, in 1903, for the macedonian students, members of the learning-literary club "Sveti Kliment", he gave three lectures on the nationality and the language of the Macedonians.
His most important literary work is Za Makedonskite raboti, which was published in Sofia in 1903. For the whole of his life Misirkov worked against the propagandas in Macedonia, fighting for the independence of the macedonian people. The ideas about the literary language and about the nationality of the Macedonians, that Misirkov was trying to spread fearlessly, came true after the freeing of Macedonia from the Fascist occupator.
Misirkov died in Bulgaria on June 26, 1926.